Why Do Kidney Stones Cause Pain?

P6140312Agonizing, intolerable, miserable, excruciating, stabbed with a knife, worse than childbirth.

As a urologist specializing in the treatment of patients with kidney stones I have learned a new lexicon exclusive to stone formers describing bouts of renal colic.

Pain, the hallmark symptom of stone disease, accounts for over one million emergency room visits by such patients in the United States each year.

Over the past several decades considerable progress has been made gaining insight into the physiology of renal colic and optimizing methods to treat it. However, despite improved scientific explanations we as clinicians still lack a perfect understanding of why it occurs.


Patients have been suffering from renal colic secondary to stone disease for over two thousand years. As a matter of fact, it is remarkable how little has changed in its clinical presentation over this time period. In 400 B.C. Hippocrates referred to it as first disease of the kidneys. He was one of the initial observers to comprehend the association between urinary obstruction and pain, writing:

An acute pain is felt in the kidney, the loins, the flank and the testis of the affected side; the patient passes urine frequently; gradually the urine is suppressed. With the urine, sand is passed; as the sand passes along the urethra, it causes severe pain which is relieved when it is expelled; then the same sufferings begin again.

We have since come to appreciate the complex physiologic basis for this relationship at a much deeper level.

How Pain Begins

renal-stonesThe first step in this process is acute obstruction, most commonly from a stone. But in stone formers masses of crystals can create obstruction, as can blood clots if bleeding is particularly brisk.

Urine from the kidney can no longer pass to the bladder and as a result builds up and stretches the proximal – closest to the kidney – ureter and renal collecting system. This stretch activates nociceptive nerve fibers – fibers which sense injury – within an entire neuronal network located submucosally in the renal pelvis, calyces, capsule and ureter.

Figure 1 (left) – Example of obstructing proximal ureteral stone with dilation and stretch of the collecting system above the level of obstruction.

These fibers then transmit afferent signals to the T11 – L1 spinal cord which the body interprets as pain at the corresponding level of neuronal activation. As the stone migrates from the kidney down the ureter and towards the bladder, pain usually shifts downward as well. It is commonly sensed as high as the upper flank when the stone is lodged in the proximal ureter and as low as the labia/testicle when down near the uretero-vesical junction at the entry to the bladder.

Patients passing stones may experience other symptoms in addition to pain.  Many of the nerves involved in the process of obstruction are intimately linked to innervation of adjacent organs, for example the gastrointestinal tract. Cross activation of these associated nerve fibers has been proposed as an explanation for the nausea and vomiting which so often occurs in the setting of an acute episode of renal colic.

In rare instances patients may even have alternative symptoms without any pain at all. In some cases, particularly when the stone is at the uretero-vesical junction, urinary symptoms predominate and the only appreciable symptoms are urinary frequency, urgency and discomfort while voiding. These symptoms mimic urinary infection and often result in temporary mis-treatment with antibiotics until the correct diagnosis is made.

What Happens Later

Increasing renal pelvis pressure from persistent obstruction causes a release of prostaglandin E2. This chemical mediator of injury response produces a perfect storm.

It causes ureteral hyperperistalsis (increased intensity of the waves of coordinated ureteral contractions which normally drive urine down to the bladder) and eventually even ureteral spasm. It also leads to dilation of the afferent arterioles – those tiny resistance vessels which control the flow of blood into the capillaries of the kidneys.

The arteriolar dilation increases blood flow to the kidney and promotes a temporary diuresis just as ureteral smooth muscle hyperperistalsis and ultimately spasm tighten the ureter around the stone and worsen obstruction. Spasm leads to lactic acid build up, as occurs when any muscle is over-exercised, and sets off an inflammatory cascade that itself can worsen pain.

With time, blood flow to the affected kidney falls, even though the arterioles which let blood into the renal capillaries remain dilated. It falls because the efferent arterioles, which let blood out of the capillaries where filtration occurs, begin to constrict and raise filtration by the renal glomerulae. The increased filtration maintains and can even raise pressures.

glomerulus copy

Figure 2 – Diagram of blood flow to the nephron.  Blood enters through the afferent arteriole and is then filtered within the glomerulus, producing urine in the process. Blood exits through the efferent arteriole. Both the afferent and efferent arteriole are able to dilate and constrict in order to regulate pressure and ultimately filtration via urine production.

In many ways, this complex system is analogous to the soaker hoses many people use to water their lawns. The afferent arterioles are the faucet the hose is connected to and the efferent arterioles are the opening at the end of the hose which can be closed or left open into a sprinkler.

Filtration is the many tiny flows of water all along the hose which keep the grass growing.

When working appropriately, the faucet and the end are both open and water (urine) is produced at a slow, constant rate (Figure 4 – left). With an obstructing stone the faucet – so to speak – is opened more and the end clamped more so more fluid – water – is filtered out along the length of the hose at high pressure (Figure 4 – right). In the kidney this filtration is into the nephrons and raises pressure. When the clamp is tightened, the total amount of flow through the hose can fall just as the amount of water filtered out along the hose rises.

Figure 4 – Soaker Hose Analogy to Renal Blood Flow and Filtration. On the left, there is little pressure in the system and water (urine) seeps out slowly from along its length.  On the right, the inflow is much higher than the outflow and water (urine) shoots out from along the hose at exceedingly high pressure.

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Three Phases of Pain in more Detail

The Physiology

No discussion regarding ureteral obstruction would be complete without the work of E. Darracott Vaughan, who characterized the physiology of urinary obstruction in the 1970’s.

Assuming two functional kidneys, the physiologic effects of acute unilatScreen Shot 2015-05-21 at 11.04.09 PMeral ureteral obstruction can be marked by three distinct phases.

In phase one, the effects of the inflammatory cascade described above cause a progressive rise in renal blood flow and renal pelvis and ureteral pressure. This phase lasts for approximately one to one and a half hours. This is the portion where the afferent arteriole – the faucet – is maximally opened.

Phase two is marked by efferent arteriolar vasoconstriction which causes a decrease in overall renal blood flow but an increase in ureteral pressure for up to five hours. The faucet is opened and the end clamp is tightened.

Phase three is marked by a further decrease in renal blood flow to the affected kidney and ultimately decreased ureteral pressure. The end clamp is progressively tightened so blood flow to the kidney is reduced enough that filtration and urine production begin to fall, and pressure with it.

Measurements of ureteral pressure (red) and renal blood flow (blue) after onset of acute unilateral ureteral obstruction. (Courtesy Campbell-Walsh Urology, Tenth Edition, Elsevier Inc.)

The fall in blood flow is not injurious during an acute attack, but over time it can be. This means that relief of an obstructing stone is an important matter. Commonly stones pass of themselves. But stone attacks need medical attention because if the stone continues to obstruct it must be removed.

The Symptoms

It is easy to conjecture how these three distinct phases correlate clinically to the symptoms experienced during an acute episode of colic.

The onset of pain classically correlates to phase one and the inciting obstructive event. It is at this point that the patient commonly seeks care in the emergency room or physician’s office.

The pain classically persists at a severe level for several hours (phase two) but ultimately subsides, at least partially (phase three).

In many instances pain comes in waves, potentially a sign of intermittent obstruction activating the above pathway each time urinary flow is obstructed. This occurs through a combination of the stone moving and the tensions of the ureter with increases or decreases of muscle spasm.

THE CONUNDRUM – Pain Without Obstruction

Opinions of Urologists in General

Though the physiologic basis of pain in the setting of obstruction is clear, it does not provide an explanation for one of the most commonly encountered conundrums in stone disease – the symptomatic non-obstructing stone. These can be actual free stones that have not passed, stones attached to plaque, or actual plugs in the kidney tubules that are massed together enough to show up on a CT scan as ‘stones’ though actually tissue calcifications.

There is perhaps as much variation in clinical opinion in such instances as any other clinical scenario in the field.

If one were to ask a group of urologists whether they believed that small nonobstructing stones could cause renal colic, opinions would range from absolute certainty to complete dismissal of the concept altogether.

What Happens to Patients

As a result, there is no standard of care regarding how to optimally manage such patients. In all cases it is first imperative to rule out other potential sources of pain; however, such workups often end with the same result – a patient with bothersome flank pain and evidence of one or more nonobstructing stones on imaging.

Lacking a physiologic explanation to explain their symptoms, patients with pain and non obstructing stones are often sent for detailed workups, secondary and tertiary consultations and referral to pain specialists and even psychiatrists. However, in an age where flexible ureteroscopy can be performed quite safely and on an outpatient basis one must wonder whether such patients are being treated appropriately.

A Specific Example

As an example, I recently met a patient who had been referred from several hours away seeking a fourth opinion regarding her chronic flank pain. For months she had suffered from a severe ache in her left flank that had limited her ability to work and live her normal life.

She had attributed the pain to a 7 mm lower pole nonobstructing renal stone on that side which was discovered on a CTScreen Shot 2015-05-21 at 2.32.24 PM scan during her initial presentation to an outside emergency room (Figure 3). However, none of the physicians she had seen agreed with her self diagnosis.

Figure 3 – CT image of left lower pole nonobstructing stone (red arrow).  There is no evidence of obstruction or inflammation around the kidney.

In the ER she was given narcotic pain medication and sent home to follow-up with a urologist.

The first urologist she saw told her that while the stone was visible, its location within the kidney meant that it could not possibly be causing her pain. He refilled her prescription for pain medication and sent her to see a pain specialist.

The pain specialist tried physical therapy for what he thought may be a musculoskeletal source but ultimately this did not prove effective and she was given more pain medication.

She later sought care from a second urologist who also told her that the stone could not possibly be causing her pain in the absence of obstruction. This time however she was accused of having an agenda and seeking care specifically to get pain medication. Similar visits to a variety of emergency rooms elicited more CT scans as well as accusations of seeking pain medications. Each CT result was the same though, all demonstrating a 7 mm non obstructing left lower pole stone.

On one instance a treating practitioner even admonished her, saying that nonobstructing stones don’t cause pain and he should know since he too had been diagnosed with such stones incidentally on a CT scan.

Ultimately she made her way to the clinic for consultation at which point she was offered a ureteroscopy and stone removal. The procedure went well and she was discharged with a stent for one week. She was last seen back 5 weeks after the procedure and reported complete resolution of her pain. She was no longer taking any pain medication whatsoever and there was no evidence of any stone or hydronephrosis on follow-up imaging.

What is Known to Date

Such patients are frequently encountered. Despite a lack of physiologic explanation as to why these non-obstructing stones may cause pain, there is emerging evidence that they do and therefore that removal can cure it.

In 2006 Taub et al. described outcomes of twenty such patients who had chronic flank pain as well as radiographically evident calcifications within their papillae without obvious collecting system stones. Ureteroscopy with laser papillotomy to unroof and remove all evident stone was performed on twenty seven kidneys. Pain improvement was seen in 85% of cases with a durable improvement for greater than one year in nearly 60% of cases.

This study was then repeated on a multi-institutional level with 65 patients undergoing similar procedures over a ten year period. Overall there were 176 procedures performed in this cohort with patients reporting less pain after the procedure 85% of the time. The mean duration of response was 26 months with 60% of patients having sustainable improvements in their pain levels for over one year.

Finally, this clinical scenario is seen commonly enough that it garnered its own nickname at Massachusetts General Hospital where it has been described as “small stone syndrome”In a retrospective review of patients treated there with ureteroscopic removal of small nonobstructing stones (<4mm) for reasons related to chronic pain, 11/13 patients reported being pain free after the procedure with the other two noting a partial response.

What I think

We still do not completely understand the physiologic explanation for pain in these patients. However, much like Hippocrates over two thousand years ago, clinical observation often precedes scientific understanding. In this regard it is unfair to dismiss the notion that small non obstructing stones can elicit legitimate renal colic.

Physiologic breakthroughs in the understanding of pain signaling and inflammation are currently happening at a rapid rate and it is likely that in time we may be able to better decipher which non-obstructing stones are truly responsible for symptoms. However, until then, such scenarios will continue to be a commonly encountered clinical complexity for urologists.

For the time being I would still advocate consideration of alternative causes of pain in such situations including urinary infection, obstruction and malignancy. A careful history is critical to rule out non-urologic sources such as pathology within the musculoskeletal, pulmonary, gynecologic and gastrointestinal systems. Another important element of the history is whether the patient has previously passed a stone and if the current symptoms are similar to that experience.

Once other explanations have been ruled out, offering stone removal is entirely reasonable. This not only has the potential to improve pain but may also decrease the risk of future stone growth or spontaneous passage at a later date. In such instances, I prefer flexible ureteroscopy with stone removal to shock wave lithotripsy. First, ureteroscopy maximizes the likelihood that all stones can be identified and removed which is especially important in the event that pain persists after the procedure. Second, with ureteroscopy one can inspect the inside of the kidney in high definition which has the potential to offer information not readily available on x-rays and CT scans such as embedded stones, tissue calcifications, and other pathology (Figure 4).

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Figure 4 – High definition images obtained during renal endoscopy demonstrating tubular plugging (stones embedded in the kidney) (Courtesy: AE Evan, IMCD and BD plugs: Do they have a role in stone formation). 

Finally, it is critical to establish realistic expectations before surgery in regards to pain control. Our understanding of this concept is in evolution and the published literature suggesting a treatment response is limited to relatively few patients. However, as science and history have shown us, just because we don’t fully understand the connection doesn’t mean it doesn’t exist.

More You Might Like

What Kidney Stones Are

Types of Kidney Stones

Do We Need to Analyse All Those Stones?

How Kidney Stones Form

When Crystals Plug The Kidneys

Medullary Sponge Kidneys





602 Responses to “Why Do Kidney Stones Cause Pain?”

  1. Kirsten Garde

    I wish there was a clinic or center that specialized in helping patients with stones when other doctors refuse to help. It is beyond disgusting that all these people are suffering and doctors refuse to take out stones especially given some of the scary facts they are linked to heart attacks too!!

    • Fredric Coe, MD

      Hi Kirsten, There are centers, and as well many urologists are very effective in stone removal. I see the main issues in stone prevention. It is not routine for many physicians – thence this site, to try to help, and Jill Harris’s course, as well. Regards, Fred Coe

    • Fredric Coe, MD

      Hi Kirsten, There are centers, and as well many urologists are very effective in stone removal. I see the main issues in stone prevention. It is not routine for many physicians – thence this site, to try to help, and Jill Harris’s course, as well. Regards, Fred Coe

  2. Irfan

    I have a 5x6mm stone in the lower ureter, close to bladder. This caused sharp pain in my right lower back. According to abdomen USG, my kidney is swollen.

    1. Is the pain caused by the stone moving down the ureter or by back pressure to the kidney created by the liquid on the way down to the bladder that is obstructed?
    2. Many people try lemons or apel cider vinegar therapy and some other and they succeeded. What is the limit that I can still continue trying the herbal therapy route without damaging the kidney sooner?

    Thank you very much.

  3. Terry

    Can a kidney cyst cause numbness and tingling in hands? I have a cyst in the left kidney and my left hand goes numb and seems to be getting worse. I have no diabetes either. This is quite odd and strange but since I have been IGNORED for so long I wonder if its now affecting my nerves.

    • Fredric Coe, MD

      Hi Terry, a renal cyst will not cause left hand tingling and numbness. Common causes are carpel tunnel syndrome – firsts two fingers, and ulnar nerve damage – little finger and outer side of ring finger. Regards, Fred Coe


    Dear Team,
    I have 6MM stone in my UV junction & i have undegone RIGHT URS on 17/01/2018 & DJ stenting on 05/02/2018. Almost 1 month passed, i have still some intermediate mild pain in my exterme Right side of abdomen(paining exactly in the same area where i have while stone exsists..). Does it is nomal?

    • Fredric Coe, MD

      Hi Sachin, The issue is whether the stone is gone. Only your surgeon is close enough to the details to be of any real help. He/she needs to be sure, usually by xray or even a brief second look with a scope. Regards, Fred Coe

  5. Debi

    So glad you posted this. I have been suffering with a 2mm kidney stone in my left kidney since Aug 2017. It has not moved, really. It causes me daily, chronic pain. I avoid taking medicines of any kind until I can’t avoid it no more. Just today, I was released from the ER because the Dr said that this same small stone is not causing me pain, even though the pain was so severe it almost caused me to pass out several times, kept my heart beat between 130-160bpm and my blood pressure 183/116. I had extreme sharp, stabbing pain that would start in my back on the left side, travel down to the front of my groin and up to the upper left side of my abdomen.
    Now, I was admitted on Jan 26 2018 for pyelonephritis. Now, today it is March 1, 2018 and I am back in the ER due to this stone in my left kidney…that I have been dealing with since Aug 2017. Yes, it is the same stone because since Aug 2017, I have been to the ER 6 times, admitted 3 times and the CT scan shows the same stone in the same place!
    My GP Dr in Houston TX said that she believes I have become tachycardia because I am in daily pain on my left side and my heart is pumping adrenaline to try to compensate for the pain. My now resting heart beat is 110 bpm. If I get up to walk to the bathroom, about 30 feet roundtrip, my heart beat will be around 120-135 bpm!
    I am here to confirm that a kidney stone, no matter the size, DOES IN FACT CAUSE PAIN JUST BEING IN THE KIDNEY.
    Thank you for this article and research.
    I am still in need of getting this stone removed so I can be relieved of this daily, chronic pain.

    • Fredric Coe, MD

      Hi Debi, given the extreme pain and numbers of ER visits I imagine your surgeon will want to remove the stone. Given the pyelonephritis, perhaps the stone is infected. I would hope the stone removal might be via ureteroscopy as that would provide a look into the kidney. Of course the surgeon is in charge of how and when things are done, and I a distant voice. Regards, Fred Coe

    • Jeff

      A POSITIVE STORY ON URETEROSCOPY!!!! I am a 56 year old male and I had mild intermittent pain on left flank for 8 months. Finally went to a Urologist and scan showed a 10mm stone in lower pole of left kidney. He told me that usually if it was in the kidney it would not cause pain and it could be Musculoskeletal problem. But he did advise me to have a Ureteroscopy to rid the stone. After reading all the horror stories I almost canceled the procedure. I am VERY GLAD I went through with it. The doctor told me what to expect through the whole thing. At 11:00 AM the procedure was under general anesthesia and was painless. I woke up with a string hanging out of my penis. Before I left the doctors office I urinated with blood and it burned pretty bad. But they said that is normal, so it didn’t bother me that much knowing that was normal.
      The rest of the day I drank water and urinated evey 15 minutes to flush it out. It burned every time and the stent caused
      a cramping pain in my kidney and bladder for 10 minutes after going. It was not easy knowing that evey time I urinated it would burn bad but knowing that was normal made it easier to push through and continue on. I only took 2 Advil every 6 hours and by midnight I felt good and my urine had very little blood. The cramping continued for several days but it would only last for 5 minutes after urinating. I felt so good the next morning that I shoveled snow which later caused blood in urine. I learned that I better take it easy. But by Day 3, I had no blood and got used to the string and never really noticed the stent.
      The doctor told me the stent needed to remain in for a week. By day 5, 6 and 7 I was feeling great and went to work.
      I felt so good I didn’t want to think about pulling the stent out. Everything I read said that pulling it out was very painfull
      and caused more bleeding. Well the morning of day 7 I laid in a hot bath an hour after taking 3 advil and was prepared for a painful experience. I decided to not hesitate and just do it. Well there was absolutely no pain at all and no blood at all!
      I worried for no reason. So all in all I’m glad that I read the horror stories to be prepared, but found out it wasn’t that bad.
      It’s been 10 days now since and the pain I had for 8 months seems to be gone.

  6. Christi

    I have a question. I am suppose to have a stone in the upper area of both kidneys. My question is would these cause pain? I have had pain in my back since November. I found out they were there when they did a CT scan. A PA in a urologists office told me they would not hurt. I’m wondering if they do because I still have back pain. It moves all over my back. Sometimes it’s flank pain, sometimes it is really low and sometimes in the middle of my back. Would this be from my kidneys? I would be so grateful for some insite on this. Thank you so much!!

    • Fredric Coe, MD

      Hi Christi, immobile stones do seem to cause pain as judged by massive amounts of similar complaints to yours. The question is always the balance between the pain and the surgery. If the pain disturbs you enough to warrant surgery the stones can be removed, preferably by ureteroscopy so as to insure stone free kidneys. Regards, Fred Coe


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