Why Do Kidney Stones Cause Pain?

P6140312Agonizing, intolerable, miserable, excruciating, stabbed with a knife, worse than childbirth.

As a urologist specializing in the treatment of patients with kidney stones I have learned a new lexicon exclusive to stone formers describing bouts of renal colic.

Pain, the hallmark symptom of stone disease, accounts for over one million emergency room visits by such patients in the United States each year.

Over the past several decades considerable progress has been made gaining insight into the physiology of renal colic and optimizing methods to treat it. However, despite improved scientific explanations we as clinicians still lack a perfect understanding of why it occurs.


Patients have been suffering from renal colic secondary to stone disease for over two thousand years. As a matter of fact, it is remarkable how little has changed in its clinical presentation over this time period. In 400 B.C. Hippocrates referred to it as first disease of the kidneys. He was one of the initial observers to comprehend the association between urinary obstruction and pain, writing:

An acute pain is felt in the kidney, the loins, the flank and the testis of the affected side; the patient passes urine frequently; gradually the urine is suppressed. With the urine, sand is passed; as the sand passes along the urethra, it causes severe pain which is relieved when it is expelled; then the same sufferings begin again.

We have since come to appreciate the complex physiologic basis for this relationship at a much deeper level.

How Pain Begins

renal-stonesThe first step in this process is acute obstruction, most commonly from a stone. But in stone formers masses of crystals can create obstruction, as can blood clots if bleeding is particularly brisk.

Urine from the kidney can no longer pass to the bladder and as a result builds up and stretches the proximal – closest to the kidney – ureter and renal collecting system. This stretch activates nociceptive nerve fibers – fibers which sense injury – within an entire neuronal network located submucosally in the renal pelvis, calyces, capsule and ureter.

Figure 1 (left) – Example of obstructing proximal ureteral stone with dilation and stretch of the collecting system above the level of obstruction.

These fibers then transmit afferent signals to the T11 – L1 spinal cord which the body interprets as pain at the corresponding level of neuronal activation. As the stone migrates from the kidney down the ureter and towards the bladder, pain usually shifts downward as well. It is commonly sensed as high as the upper flank when the stone is lodged in the proximal ureter and as low as the labia/testicle when down near the uretero-vesical junction at the entry to the bladder.

Patients passing stones may experience other symptoms in addition to pain.  Many of the nerves involved in the process of obstruction are intimately linked to innervation of adjacent organs, for example the gastrointestinal tract. Cross activation of these associated nerve fibers has been proposed as an explanation for the nausea and vomiting which so often occurs in the setting of an acute episode of renal colic.

In rare instances patients may even have alternative symptoms without any pain at all. In some cases, particularly when the stone is at the uretero-vesical junction, urinary symptoms predominate and the only appreciable symptoms are urinary frequency, urgency and discomfort while voiding. These symptoms mimic urinary infection and often result in temporary mis-treatment with antibiotics until the correct diagnosis is made.

What Happens Later

Increasing renal pelvis pressure from persistent obstruction causes a release of prostaglandin E2. This chemical mediator of injury response produces a perfect storm.

It causes ureteral hyperperistalsis (increased intensity of the waves of coordinated ureteral contractions which normally drive urine down to the bladder) and eventually even ureteral spasm. It also leads to dilation of the afferent arterioles – those tiny resistance vessels which control the flow of blood into the capillaries of the kidneys.

The arteriolar dilation increases blood flow to the kidney and promotes a temporary diuresis just as ureteral smooth muscle hyperperistalsis and ultimately spasm tighten the ureter around the stone and worsen obstruction. Spasm leads to lactic acid build up, as occurs when any muscle is over-exercised, and sets off an inflammatory cascade that itself can worsen pain.

With time, blood flow to the affected kidney falls, even though the arterioles which let blood into the renal capillaries remain dilated. It falls because the efferent arterioles, which let blood out of the capillaries where filtration occurs, begin to constrict and raise filtration by the renal glomerulae. The increased filtration maintains and can even raise pressures.

glomerulus copy

Figure 2 – Diagram of blood flow to the nephron.  Blood enters through the afferent arteriole and is then filtered within the glomerulus, producing urine in the process. Blood exits through the efferent arteriole. Both the afferent and efferent arteriole are able to dilate and constrict in order to regulate pressure and ultimately filtration via urine production.

In many ways, this complex system is analogous to the soaker hoses many people use to water their lawns. The afferent arterioles are the faucet the hose is connected to and the efferent arterioles are the opening at the end of the hose which can be closed or left open into a sprinkler.

Filtration is the many tiny flows of water all along the hose which keep the grass growing.

When working appropriately, the faucet and the end are both open and water (urine) is produced at a slow, constant rate (Figure 4 – left). With an obstructing stone the faucet – so to speak – is opened more and the end clamped more so more fluid – water – is filtered out along the length of the hose at high pressure (Figure 4 – right). In the kidney this filtration is into the nephrons and raises pressure. When the clamp is tightened, the total amount of flow through the hose can fall just as the amount of water filtered out along the hose rises.

Figure 4 – Soaker Hose Analogy to Renal Blood Flow and Filtration. On the left, there is little pressure in the system and water (urine) seeps out slowly from along its length.  On the right, the inflow is much higher than the outflow and water (urine) shoots out from along the hose at exceedingly high pressure.

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Three Phases of Pain in more Detail

The Physiology

No discussion regarding ureteral obstruction would be complete without the work of E. Darracott Vaughan, who characterized the physiology of urinary obstruction in the 1970’s.

Assuming two functional kidneys, the physiologic effects of acute unilatScreen Shot 2015-05-21 at 11.04.09 PMeral ureteral obstruction can be marked by three distinct phases.

In phase one, the effects of the inflammatory cascade described above cause a progressive rise in renal blood flow and renal pelvis and ureteral pressure. This phase lasts for approximately one to one and a half hours. This is the portion where the afferent arteriole – the faucet – is maximally opened.

Phase two is marked by efferent arteriolar vasoconstriction which causes a decrease in overall renal blood flow but an increase in ureteral pressure for up to five hours. The faucet is opened and the end clamp is tightened.

Phase three is marked by a further decrease in renal blood flow to the affected kidney and ultimately decreased ureteral pressure. The end clamp is progressively tightened so blood flow to the kidney is reduced enough that filtration and urine production begin to fall, and pressure with it.

Measurements of ureteral pressure (red) and renal blood flow (blue) after onset of acute unilateral ureteral obstruction. (Courtesy Campbell-Walsh Urology, Tenth Edition, Elsevier Inc.)

The fall in blood flow is not injurious during an acute attack, but over time it can be. This means that relief of an obstructing stone is an important matter. Commonly stones pass of themselves. But stone attacks need medical attention because if the stone continues to obstruct it must be removed.

The Symptoms

It is easy to conjecture how these three distinct phases correlate clinically to the symptoms experienced during an acute episode of colic.

The onset of pain classically correlates to phase one and the inciting obstructive event. It is at this point that the patient commonly seeks care in the emergency room or physician’s office.

The pain classically persists at a severe level for several hours (phase two) but ultimately subsides, at least partially (phase three).

In many instances pain comes in waves, potentially a sign of intermittent obstruction activating the above pathway each time urinary flow is obstructed. This occurs through a combination of the stone moving and the tensions of the ureter with increases or decreases of muscle spasm.

THE CONUNDRUM – Pain Without Obstruction

Opinions of Urologists in General

Though the physiologic basis of pain in the setting of obstruction is clear, it does not provide an explanation for one of the most commonly encountered conundrums in stone disease – the symptomatic non-obstructing stone. These can be actual free stones that have not passed, stones attached to plaque, or actual plugs in the kidney tubules that are massed together enough to show up on a CT scan as ‘stones’ though actually tissue calcifications.

There is perhaps as much variation in clinical opinion in such instances as any other clinical scenario in the field.

If one were to ask a group of urologists whether they believed that small nonobstructing stones could cause renal colic, opinions would range from absolute certainty to complete dismissal of the concept altogether.

What Happens to Patients

As a result, there is no standard of care regarding how to optimally manage such patients. In all cases it is first imperative to rule out other potential sources of pain; however, such workups often end with the same result – a patient with bothersome flank pain and evidence of one or more nonobstructing stones on imaging.

Lacking a physiologic explanation to explain their symptoms, patients with pain and non obstructing stones are often sent for detailed workups, secondary and tertiary consultations and referral to pain specialists and even psychiatrists. However, in an age where flexible ureteroscopy can be performed quite safely and on an outpatient basis one must wonder whether such patients are being treated appropriately.

A Specific Example

As an example, I recently met a patient who had been referred from several hours away seeking a fourth opinion regarding her chronic flank pain. For months she had suffered from a severe ache in her left flank that had limited her ability to work and live her normal life.

She had attributed the pain to a 7 mm lower pole nonobstructing renal stone on that side which was discovered on a CTScreen Shot 2015-05-21 at 2.32.24 PM scan during her initial presentation to an outside emergency room (Figure 3). However, none of the physicians she had seen agreed with her self diagnosis.

Figure 3 – CT image of left lower pole nonobstructing stone (red arrow).  There is no evidence of obstruction or inflammation around the kidney.

In the ER she was given narcotic pain medication and sent home to follow-up with a urologist.

The first urologist she saw told her that while the stone was visible, its location within the kidney meant that it could not possibly be causing her pain. He refilled her prescription for pain medication and sent her to see a pain specialist.

The pain specialist tried physical therapy for what he thought may be a musculoskeletal source but ultimately this did not prove effective and she was given more pain medication.

She later sought care from a second urologist who also told her that the stone could not possibly be causing her pain in the absence of obstruction. This time however she was accused of having an agenda and seeking care specifically to get pain medication. Similar visits to a variety of emergency rooms elicited more CT scans as well as accusations of seeking pain medications. Each CT result was the same though, all demonstrating a 7 mm non obstructing left lower pole stone.

On one instance a treating practitioner even admonished her, saying that nonobstructing stones don’t cause pain and he should know since he too had been diagnosed with such stones incidentally on a CT scan.

Ultimately she made her way to the clinic for consultation at which point she was offered a ureteroscopy and stone removal. The procedure went well and she was discharged with a stent for one week. She was last seen back 5 weeks after the procedure and reported complete resolution of her pain. She was no longer taking any pain medication whatsoever and there was no evidence of any stone or hydronephrosis on follow-up imaging.

What is Known to Date

Such patients are frequently encountered. Despite a lack of physiologic explanation as to why these non-obstructing stones may cause pain, there is emerging evidence that they do and therefore that removal can cure it.

In 2006 Taub et al. described outcomes of twenty such patients who had chronic flank pain as well as radiographically evident calcifications within their papillae without obvious collecting system stones. Ureteroscopy with laser papillotomy to unroof and remove all evident stone was performed on twenty seven kidneys. Pain improvement was seen in 85% of cases with a durable improvement for greater than one year in nearly 60% of cases.

This study was then repeated on a multi-institutional level with 65 patients undergoing similar procedures over a ten year period. Overall there were 176 procedures performed in this cohort with patients reporting less pain after the procedure 85% of the time. The mean duration of response was 26 months with 60% of patients having sustainable improvements in their pain levels for over one year.

Finally, this clinical scenario is seen commonly enough that it garnered its own nickname at Massachusetts General Hospital where it has been described as “small stone syndrome”In a retrospective review of patients treated there with ureteroscopic removal of small nonobstructing stones (<4mm) for reasons related to chronic pain, 11/13 patients reported being pain free after the procedure with the other two noting a partial response.

What I think

We still do not completely understand the physiologic explanation for pain in these patients. However, much like Hippocrates over two thousand years ago, clinical observation often precedes scientific understanding. In this regard it is unfair to dismiss the notion that small non obstructing stones can elicit legitimate renal colic.

Physiologic breakthroughs in the understanding of pain signaling and inflammation are currently happening at a rapid rate and it is likely that in time we may be able to better decipher which non-obstructing stones are truly responsible for symptoms. However, until then, such scenarios will continue to be a commonly encountered clinical complexity for urologists.

For the time being I would still advocate consideration of alternative causes of pain in such situations including urinary infection, obstruction and malignancy. A careful history is critical to rule out non-urologic sources such as pathology within the musculoskeletal, pulmonary, gynecologic and gastrointestinal systems. Another important element of the history is whether the patient has previously passed a stone and if the current symptoms are similar to that experience.

Once other explanations have been ruled out, offering stone removal is entirely reasonable. This not only has the potential to improve pain but may also decrease the risk of future stone growth or spontaneous passage at a later date. In such instances, I prefer flexible ureteroscopy with stone removal to shock wave lithotripsy. First, ureteroscopy maximizes the likelihood that all stones can be identified and removed which is especially important in the event that pain persists after the procedure. Second, with ureteroscopy one can inspect the inside of the kidney in high definition which has the potential to offer information not readily available on x-rays and CT scans such as embedded stones, tissue calcifications, and other pathology (Figure 4).

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Figure 4 – High definition images obtained during renal endoscopy demonstrating tubular plugging (stones embedded in the kidney) (Courtesy: AE Evan, IMCD and BD plugs: Do they have a role in stone formation). 

Finally, it is critical to establish realistic expectations before surgery in regards to pain control. Our understanding of this concept is in evolution and the published literature suggesting a treatment response is limited to relatively few patients. However, as science and history have shown us, just because we don’t fully understand the connection doesn’t mean it doesn’t exist.

More You Might Like

What Kidney Stones Are

Types of Kidney Stones

Do We Need to Analyse All Those Stones?

How Kidney Stones Form

When Crystals Plug The Kidneys

Medullary Sponge Kidneys





559 Responses to “Why Do Kidney Stones Cause Pain?”

  1. Penny

    I am a 69 years old female, recently diagnosed with mild gout. This was a wakeup call to live a more healthy lifestyle. I have stopped eating sugar, have always watched my fat and protein intake, rather eat vegetables and whole wheat breads. Eliminating sugar (sugary drinks, pastries, hidden sugars in foods, etc.) has had a positive effect, I have lost 37 lbs, lowered uric acid levels, triglycerides are normal, normal blood glucose levels,etc. This is all great, but now I seem to be developing a kidney stone. I will be having a catscan this week to be sure, but I am confused. I have pain on right side of lower back, along the side, circling around to the front, but it is fairly mild to medium pain that comes and goes during the day. I also feel a lot of pressure at the site. My doctor did a urine test that showed a mild amount of blood in my urine, hence the catscan. Everything I’ve heard from family/friends and what I’ve read is that stones cause very strong pain…so my question is, why is my pain so low, is low pain common, and is my stone just at it’s beginnings as to pain?

    • Penny

      Oops, meant pain is on my left side. Sometimes I get a little dyslexic.

    • Fredric Coe, MD

      Hi Penny, The CT scan is a very good idea. If there is a stone, uric acid would be a good bet given gout. The radiologist can help assess if that is the case. Whatever the case, you should want to prevent more. Try this article. Regards, Fred Coe

  2. Darcie Hall

    Hi Dr. Coe,

    Sorry to bother you. I found your article after much searching for some of the symptoms I’ve been experiencing. I’ve been fighting with kidney stones for the first time in my life for the last 7 weeks. I had a 5mm obstructing (which passed), a 4mm obstructing (which also passed), and a 3 mm non obstructing that I have every reason to believe passed yet have not had a CT scan or Xray to confirm (as my urologist keeps asking me to have the Xray to verify the presence of stones.) I have been feeling great since last Sunday, exactly one week ago, where I was sure I had passed the latter mentioned stone. Today I was going grocery shopping and at the end of my journey, suddenly my lower back all along my sacroiliac area began to hurt so incredibly badly that I couldn’t walk or stand. I am having left lower flank and left groinal pain, similar to when I had the other stones but not as bad, but the pain in my lower back is so severe I can’t stay in one position for more than 15 minutes, I can’t toilet myself, I keep crying…I hate to go back to the ER again but my urologist keeps basically saying he can’t do anything to help me. I am at my wit’s end and only have motrin and tylenol to help with the pain. Any suggestions? Thank you for your time, sir.

    Darcie Hall

    • Darcie Hall

      I should also mention that the ER physician mentioned in my last CT with intravenous and ingested contrast that there seems to be more stones in my kidney, I think. It’s hard to remember exactly what he said because I was in so much pain it was hard to think straight. I just have no idea what could be causing this as I have lost almost 100 lbs and am eating healthier now, drinking only water with 1 cup of coffee a week, and moving more than I have in years. I have Fibromyalgia but it has NEVER affected me to this degree, although I am aware that it may be contributing to the intensity of my pain. I’m checking out your link I saw posted below entitled “Putting It All Together”.

      • Fredric Coe, MD

        Hi Darcie, You have found a most useful useful link. It links to other more detailed articles, as well. Losing 100 pounds sounds like a possible reason things started up. You need management of what I suspect is a current stone, and evaluation so you can prevent more. Regards, Fred Coe

    • Fredric Coe, MD

      Hi Darcie, I would imagine another stone, and a new CT or ultrasound is in order. I would be sure and get the new imaging. But prevention is crucial. Here is a good place to start when your pain is better. Of major import, collect stones and get them analysed! Regards, Fred Coe

  3. Kristy Abell

    Does a kidney infection hurt just as much as kidney stone? I dont have stone aa I passed it on my own so nothing is there but was told I have infection. Same stabbing pain as well aa lower back pain. Can an infection cause this and why do kidney infections hurt so much? Thanks

    • Fredric Coe, MD

      Hi Kristy, infections can hurt because of inflammation. But be sure about that stone. Have your surgeon be sure none are obstructing a kidney. They can tell but only if you bring your symptom to them. Regards, Fred Coe

      • Kristy Abell

        Is it possible that a CT scan can miss stones? I also had a nuclear renal scan done. Strange because I passed the one stone but my other kidney feela like I might have another yet its not showing up anywhere on imaging and have that similar stabbing pain and it literally feels like I have a “something” inside my kidney.

        • Fredric Coe, MD

          Hi Kristy, CT scans are very sensitive. If negative, probably no stones remains in the kidneys or urinary tract. But the latter is a big place, and sometimes a stone can be missed at the junction of the bladder and ureter. I am sure your urologist has looked as carefully as she/he can. Regards, Fred Coe

  4. Scott

    Good Day, Dr. Coe. I have been experiencing shoulder pain (both sides, equally) for nearly 2 months. My doctor ran bloodwork for arthritis, Lyme disease, etc. several weeks ago – all which came back negative. I was prescribed Naproxen – which seemed to alleviate the pain until my neurosurgeon told me I can not take it due to a cervical fusion in mid-August of this year (there is apparently a 6 month wait after fusion surgery before taking NSAID’s due to inhibiting bone growth). Yesterday, at 5:00pm, I began to experience continual urinary issues (where I felt like my bladder was full but could only manage a few dribbles of urine at a time). At the same time, I began experiencing what felt like constipation pain – though I had a bowel movement just hours earlier. Several hours later, I began experiencing rolling (contraction type) sharp pain in my lower, right abdomen – and subsequently in my lower, right back. The 3rd episode brought me to my knees in writhing pain – at which time I went to the ER. Via CT Scan, it was confirmed that I had a 3mm kidney stone and was given morphine intravenously for the pain. Via bloodwork, it was determined that I also had low potassium (everything else checked out okay) – so I was given 2 potassium pills in the ER also. Due to the stone size, I was informed that it would pass on its own, given prescriptions for Norco (pain), Zofran (nausea) and Flomax to help open passage for the stone and sent home. At this point, I have not had discoloration of my urine (blood/pink/brown). My question is two-fold: 1) My shoulder pain seems to have subsided for the first time in months (even before getting the Morphine and taking the Norco). Is it possible that the stone was the culprit of my shoulder pain this whole time but is now diminished due to the stone moving downward? 2) Once the ER Morphine wore off, the abdominal/back pain returned (even after taking my first Norco). It lasted for another couple hours and then dissipated. I was able to urinate freely this morning and have been using a strainer to check for stone discharge (nothing as of yet). With no pain and urinating freely now, can I assume that the stone is now in my bladder awaiting it’s decent down my urethra as some point? And if that’s the case, how long should I wait before becoming concerned if I do not see stone discharge via strainer examination?

    • Scott

      And I forgot to mention that the CT Scan showed the stone closer to the bladder than to the kidney – so it had obviously been travelling downward for 3 to 4 hours (from pain onset to CT imaging).

    • Fredric Coe, MD

      Hi Scott, I put nothing past stones – they can cause all kinds of pain. You cannot assume the stone is gone, however, as obstruction can be silent and injure kidneys. Have your urologist evaluate matters for you. By the way, prevention matters. Here is a decent place to start. Regards, Fred Coe

  5. Barb

    I am very worried. I have constant stabbing kidney pain, and pelvic pain. I also have very sharp lower back pain. I have never experienced anything so terribly painful. I am told stones inside kidney should not cause this pain. Told to go to a pain specialist. Stone is 5mm. Could all this pain be caused by a stone ? Im a single mother and my daughter needs me. I can barely function. What do I do?

    • Fredric Coe, MD

      Hi Barb, We are finding that small stones can indeed cause pain. Given your story I would speak with your urological surgeon about the possibility of ureteroscopic removal of the one stone in case that will cure you. Regards, Fred Coe

  6. Sandra

    I have no stones but a cyst that is a bit over 2cm. I have terrible pain on the side of the cyst, side pain, abdominal, and back pain. I am told it shouldnt cause pain, well IT IS.. as there is nothing else wrong with me! Someone told me they had it aspirated and it help relieve their pain, but they are in Europe. I am looking for someone that can aspirate this cyst anywhere in America! I honestly do not understand why patients are left suffering with stones or cysts when the procedures are simple and effective for removing both! It is mind boggling to me!!

    • Fredric Coe, MD

      Hi Sandra, I am not an expert concerning surgery of cysts, but I agree it is generally straightforward. I am not sure if it is aspirated, or treated via laparoscopic procedure, but in the US are many surgeons who can help. If you tell me where you live, I can make some suggestions. If you wish, the cyst can be treated here at University of Chicago if it is convenient for you. Regards, Fred Coe

      • Sandra

        Thank you for quick reply. In Buffalo NY, but am willing to go anywhere I can get proper care. I am told it is a fairly simple procedure too.

        • Fredric Coe, MD

          The university hospital in ROchester has a good kidney stone program, and skilled surgeons. I would suggest calling them. Regards, Fred Coe

  7. Gary

    I had stones and was always told the pain was back pain as stones inside a kidney dont cause pain. Well I ended up visiting a urologist in another country. I had them removed and the pain stopped. I had back pain, pains on my sides, my abdominal pain and sharp lower back pain as well. Some nights I felt like I was dying, and it seemed never ending. Movement made it worse at times and other times better. Mine were 4 to 6mm in size. Something should be done about this, because its not right dismissing patients and telling them its back pain when it isnt. Kidney stone pain is worse than anything I experienced, the stabbing intensity of the pain.. I dont with this pain upon my worse enemy. And NONE of my stones were obstructing anything.

    • Fredric Coe, MD

      Hi Gary, You are part of a vanguard of people with a similar story. Small non obstructing stones seem to cause pain, and we need to get a trial of surgery organized. Thanks for sharing. Regards, Fred Coe

      • Gary

        Thanks for quick reply. Yes, that would be great. A lot of folks suffering out there and taking heavy pain meds for something that can be easily resolved.

  8. Deana

    Hi Dr. Coe,
    I’m a 39 year old female. I just got the results of my 24hr urine test and it showed oxalate fine at 32, but uric acid over the norm, at 715. My PH was 6.8 and citrate is 671. I had an 8mm calcium oxalate stone that was removed in January. The paper said ‘Patient has Hyperuricosuria. Suspected cause: Hyperuricosuric Nephrolithiasis.’ I thought PH over 6 decreased the uric acid in urine? What do I do now?

    • Fredric Coe, MD

      Hi Deana, I started this 40 years ago when I described high urine uric acid in calcium oxalate stone formers and showed their stone rate fell with allopurinol – a drug that lowers urine uric acid. A formal trial confirmed my work but I never figured out the mechanism. What I would do is just lower my protein intake a bit – uric acid comes from beef and poultry – cell nuclei degrade to it. Regards, Fred Coe


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